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Abstract
Tissue engineering is the discipline that deals with the regeneration of damaged tissues. Nanofibers are the most acceptable substances for the regeneration of tissues because it mimics the Extracellular cellular matrix (ECM), so the cells can easily proliferate on it. Natural polysaccharides are used for the development of nanofibers because of their biocompatibility and biodegradability. But certain limitations are also associated with these natural polysaccharides such as low mechanical property, so chemically derived polymers are also incorporated with the natural polysaccharides to overcome this limitation. Nanofibers can be procured using various techniques, among them electrospinning is the most favored technique.[1]
In this perspective we aim to explore the combination of Polyvinyl alcohol (PVA) and neem gum (NG) for the fabrication of nanofibers using electrospinning technique. Various grades of nanofibers were prepared by varying the concentration of PVA and NG. The preparation of nanofibers was confirmed using various analytical techniques.[2] The antimicrobial activity of PVA, NG and PVA/NG nanofiber was investigated against bacteria such as Staphylococcus aureus and Escherichia coli using the disk diffusion method. Nutrient agar media was used for the incubation of bacteria. The NG and PVA/NG nanofiber has the potential to inhibit the growth of bacteria. This suggests that the nanofiber will provide a framework for the proliferation of cells as well as have the ability to treat the infections caused by bacteria.[3]
Keywords: Nanofiber, Neem Gum (NG), PVA, electrospinning, antimicrobial activity.
References
[1] L. Bacakova, M. Zikmundova, J. Pajorova, A. Broz, E. Filova, A. Blanquer, R. Matejka, J. Stepanovska, P. Mikes, V. Jencova, E. Kuzelova Kostakova, A. Sinica, Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Synthetic Polymers, Appl. Nanobiotechnology. (2020). https://doi.org/10.5772/intechopen.88744.
[2] N.T.B. Linh, Y.K. Min, H.Y. Song, B.T. Lee, Fabrication of polyvinyl alcohol/gelatin nanofiber composites and evaluation of their material properties, J. Biomed. Mater. Res. - Part B Appl. Biomater. 95 (2010) 184–191. https://doi.org/10.1002/jbm.b.31701.
[3] A. Kumar, S. Sharma, S. Afgan, R. Kumar, A. Kumar, R. Srivastava, International Journal of Biological Macromolecules Development of graft copolymer of carboxymethylcellulose and N -vinylcaprolactam towards strong antioxidant and antibacterial polymeric materials, Int. J. Biol. Macromol. 112 (2018) 780–787. https://doi.org/10.1016/j.ijbiomac.2018.02.030.