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Abstract
Disease associated with the cardiovascular problem is the foremost cause of lethality in the world, and people having hyperlipidaemia are twice the risk of developing CVD as compared to those with normal lipid levels. High level of lipid in the blood causes deposition of plaques in the artery wall and blocking the blood flow. Therefore, early detection and cure is necessary to reduce cardiovascular events and sudden deathblow. The present study aims to investigate the lipid lowering potential in fruit peel of plant Trapa bispinosa.
The anti-hyperlipidaemic potential of methanolic extract of Trapa bispinosa (family- Lythraceae) fruit peel has been evaluated in high fat diet induced mice model using different in-vitro and in-vivo parameters. Lipid profile, body weight, liver weight parameters have been evaluated in control and diseased animals. The results of phytochemicals screening reveal the presence of secondary metabolites in the extract including alkaloids, saponins, glycosides, steroids, flavonoids, tannins, and phenols. The results of DPPH and Superoxide free radical scavenging assay suggest the antioxidant potential, however, biochemical estimations along with the histopathological evaluation confirm the antihyperlipidemic potential of extract. Thus, all the results confirm the lipid lowering potential of methanolic extract of Trapa bispinosa fruit peel in high fat diet induced hyperlipidaemia in mice, proving its therapeutic usefulness in the treatment of hyperlipidaemic conditions.