Speaker
Description
Today, the whole world is facing the problem of resistant microbial infections, wherein, tuberculosis (TB) is not the exception. TB has drastically been observed for resistant infections such as multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) infections. In present study, we have synthesized 10 new hydrazones using greener and eco-friendly synthesis using biodegradable Chitosan HCl as a catalyst. Reactions were accomplished within short span of time 15–30 min at room temperature conditions. Furthermore, we have also carried out molecular docking analysis in order to establish the predicted binding modes. Further, DFT analysis was also carried out to study correlate electronic properties of molecules with bioactivity study, i.e., anti-TB assay using Microplate Alamar Blue Assay. One of our compounds retained a lower toxicity (electrophilicity index (ω) 3.1304), low chemical hardness (η: 2.1740), and high softness (S: 0.4600). Considering previous background of literature on hydrazones and current findings, we believed that hydrazones would be more established as lead cores in near drug discovery.