Speaker
Description
Abstract:
Flavonoids are highly used natural phenolic compounds, which have shown potential role in wound healing. Many preclinical studies have indicated that these flavonoids are one of the most promising and important group of natural compounds which can be used to treat acute as well as chronic wounds. Flavonoids show such excellent properties due to the presence of hydroxyl groups in its chemical structure which makes this class of compounds different from others. Flavonoids can be classified as flavones, isoflavones, flavonols, flavanones and anthocyanidins respectively. Naringin, the glycone part and naringenin the aglycone part falls under the broad umbrella of flavonoid class (flavanones) which are majorly obtained from various citrus fruits like lemon, orange, grapefruit. Several therapeutic roles have been documented for naringenin, such as anti-inflammatory, antioxidant, antiulcer, anticancer, wound healing activities. Due to low solubility of this natural compound, delivery is much challenging. Fabrication of this compound using nanotechnological platform brought to us hopes to deliver and made them bioavailable for the treatment of several diseases. As reported in the literature, naringenin nanocarriers could show wonderful therapeutic efficiency in different experimental wound models based on its mixed chemical nature and potential. This presentation has focused on the beneficial role of naringenin towards healing of different wound conditions with special emphasis on exploring the underlying mechanisms.
Keywords: Flavonoids; naringenin; nanotechnology; drug delivery; wound healing; mechanism of actions.