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Description
ABSTRACT:
The study aims to identify suitable nanocarrier systems for encapsulation of polyphenols for protection against various cardiovascular diseases. Data was collected from databases including PubMed and Google Scholar to identify the total number to work done on various polyphenols utilizing nanotechnology as an approach for maximizing their therapeutic potential. The reports collected were screened and selected for further study. The various nanoparticle-based delivery systems that have been developed for the entrapment of polyphenols and circumvent the pitfalls of poor systemic availability have been elaborately discussed. The results show that nanotechnology is a versatile and promising approach towards circumventing the pharmacological limitations of polyphenols. They serve as efficient carriers for targeted-drug delivery thus minimizing extra-cellular effects. However, it was seen that compared to other diseases, study in the field of nano-encapsulated polyphenols against cardiovascular disorders is still at its infancy and opens a huge avenue for further research. This study elucidates recent developments in nanotechnology that could not only be imperative to cardiovascular disease alleviation but also in resolving issues of safety and specificity associated with these molecules. It also highlights the improved physicochemical properties and possible molecular mechanisms of some major polyphenols administered as nano-formulations and describes the results of in-vitro and in-vivo studies carried out in animal models of cardiovascular diseases (CVDs).