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Description
The water-soluble phenolic compounds known as phenylethanoid glycosides (PhGs) are found in a variety of medicinal plants. Over 572 PhGs have been discovered and characterised as of June 2020. They are distinguished by a phenethyl alcohol component joined by a glycosidic bond to a β-glucopyranose/β-allopyranose. PhGs are significant in medicinal chemistry research due to their exceptional activity in a variety of diseases. Phenylethanoid glycosides are derived from a variety of resources and exhibit potent biological and pharmacological properties, including neuroprotective effects, antioxidant, antibacterial, antivirus, anti-inflammatory, antidiabetic, antiobesity, anticancer, cytotoxic etc. PhGs' limited bioavailability and intestinal malabsorption has hindered them from fulfilling their therapeutic applications in spite of these positive effects. Phenylethanoid glycosides themselves have been shown to have a various of physiological properties, even though there are still some issues, such as varying standards and imprecise delivery. In order to enhance the bioavailability of active component, delivery systems are an effective approach. Bioenhancers and nanotechnology have recently made strides in improving the bioavailability of PhGs. As a result, additional research should be done on the delivery strategy, action mechanism, and applications of phenylethanoid glycosides.
Keywords: Phenylethanoid glycosides, Bioavailability, Delivery systems