Speaker
Description
Nanotechnology, an innovative strategy, is a recent and quickly emerging field in pharmaceutical and medical research. Applications of nanotechnology in plant systems, or “Phyto-nanotechnology,” have gained considerable interest as it improves therapeutic advantages. Albumin, a versatile distinctive protein because of its various properties like high compatibility, non-immunogenicity, biodegradability, and high safety profile, is now regarded as the most commendable carrier for drug delivery. Plants contain bioactive molecules called phytochemicals found in vegetables, fruits, grains, and other plant parts that provide health-related advantages and help defend the body from disease, besides providing basic nutrition. However, their usage has been limited because of their relatively low solubility, stability, bioavailability, target specificity, and adverse affects at large doses. In place of conventional formulations, albumin-based nano-carriers hold a massive potential in delivering various phytoconstituents in the therapy of multiple types of cancers, in the treatment of Parkinson's disease, and in tissue regeneration. Anti-cancer phytoconstituents such as Gambogic Acid and Forskolin are delivered using albumin-based nanoparticles. Curcumin, a polyphenolic phytoconstituent, has a potential anti-Parkinson action and is delivered using albumin-based nanoparticles. Phytoconstituents also have applications in tissue regeneration and regenerative medicine because of their healing, anti-oxidative, anti-inflammatory, and anti-bacterial properties. Albumin nanoparticles loaded with resveratrol, trapped inside a 3-dimensional scaffold, finds their application in bone tissue regeneration. Thus, albumin nanoparticles served as a versatile carrier in phytoconstituent delivery and had expanded the scope of phytoconstituent in various therapies. .
Keywords: phyto-nanotechnology, albumin nanoparticles, phytoconstituent delivery, anti-cancer, anti-Parkinson, tissue regeneration.