Speaker
Description
In diabetic patients delayed wound healing and chronic wounds are major complications that have been a reason of serious concern. A decrease in the proliferation and migration of different cells like keratinocytes and fibroblasts are considered to be the major reason behind the development of such wounds. Thereby, designing a wound dressing patch using a biodegradable hydrogel which can provide a sustained release of active agents that can support cell proliferation and cell migration that will be highly beneficial for promoting diabetic wound healing. Due to its excellent biocompatibility, effective cell penetration, high fluorescence and specific adsorption of nucleotides, GO-derivatives have been identified in a wide range of biomedical applications. The two main methods for producing GO-based wound dressings are solvent blending method and in-situ polymerization. Several indications from both in-vitro and in-vivo studies have revealed that graphene oxide (GO) and reduced graphene oxide promote wound healing by enhancing migration and proliferation of keratinocytes. In addition GO possesses angiogenic properties that have an active role in any inflammatory event.
Keywords: Graphene Oxide, reduced graphene oxide, hydrogel, biocompatibility.