Speaker
Description
Lipid–polymer hybrid nanoparticles (LPHNPs) are core-shell nanostructures, which comprise cores of polymer and lipid shells, that demonstrate the properties of polymeric nanoparticles and liposomes, especially regarding physical stability and biocompatibility. LPHNPs overcome the limitations such as structural disintegration and the short circulation time of lipid nanocarriers. This study aims to develop a Quality by Design (QbD) based nanocarrier formulation design for curcumin delivery. We attempted a one-step approach that includes coexisting polymeric and lipid self-assembly instead of a conventional two-step process design for hybrid delivery systems. Because of its two-in-one structure, the lipid-polymer hybrid nanocarrier approach is of particular interest for the development of a more stable, robust and convenient formulation design. Polymer-lipid hybrid nanoparticles (PLHNPs) are formed by combining lipid films and polymeric nanoparticles in the same solvent phase and fabricated in self-assembly vesicular structures with enhanced drug payload, controlled drug release, increased circulation time, stability, and superior in vivo efficacy from both components. Polymer-lipid hybrid nanoparticles (PLHNPs) were prepared by a rotary evaporator method and optimized for curcumin loading and entrapment efficiency. Our study focused on identifying critical material attributes which include drug ratio, lipids: polymer ratio and solvent. We use Box-Behnken design for understanding the multiple factors and their interactions influencing the product. The output correlation has reflected that the developed method can be used for the easy fabrication of polymer-lipid hybrid structures.
Keywords: Lipid polymer hybrid nanoparticles, QbD, Lipid films, Targeting Drug delivery