Speaker
Description
Nowadays solid dispersion is one of the popular strategies for enhancing solubility and bioavailability of poorly soluble drugs. A variety of methods are used to develop the formulation of solid dispersion using drugs and carriers in different ratios. The selection of carrier and solvent should be compatible with the drug. First, the pre-formulation studies of drugs and polymers are carried out. The characterization of solid dispersion was done with solubility studies, Fourier Transform Infrared, Differential Scanning Calorimetry, and Powder X-Ray Diffraction. In-vitro testing was performed using dissolution studies. It has been observed that solid dispersions enhance the aqueous solubility of poorly soluble drugs. The Fourier Transform Infrared helps in the identification of functional groups and shows possible weak interactions such as hydrogen bonding, covalent interaction, etc. The results of Differential Scanning Calorimetry and Powder X-Ray Diffraction help to indicate that the drug changes its nature from a crystalline to an amorphous state. The dissolution rate of solid dispersion becomes faster than that of individual drugs. Thus, solid dispersion can be used as a promising technique to improve the solubility and bioavailability of poorly soluble drugs.