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Description
Microsponges have become research of interest in the recent times due to its extremely porous matrix, non-collapsible nature, highly cross-linked structure, improved stability, high drug entrapment efficiency, and controlled drug release. Verbascoside is a water soluble phenylpropanoid glycoside which have shown potential antimicrobial activity. The present study is designed to formulate the verbascoside-loaded microsponge gel with the objective to achieve the various biological activities. Therefore, the preparation of microsponge gel entail the quasi-emulsion solvent diffusion technique using required amounts of ethyl cellulose and polyvinyl alcohol as carriers. The microsponges was then characterized by techniques including, FTIR, XRD, DSC, SEM, drug content evaluation, and entrapment efficiency. The preparation is further loaded in Carbopol gel matrix to achieve the future goal of topical drug delivery for wound healing. The formulation was further accessed for its pH, viscosity, spread-ability, drug release, and other mechanical properties. So, this study ameliorates the knowledge regarding the verbascoside microsponge formulation. Also, highlighting its antimicrobial activity by zone of inhibition method.
Keywords: Biological activity; Entrapment efficiency; Microsponge gel; Verbascoside.