Description
Objective: The present study is concerned with the formulation and In vitro evaluation of Dextromethorphan floating tablets using central composite design. Methodology: The dextromethorphan floating tablets were prepared using direct compression method. Drug excipient compatibility studies were performed through FT-IR and DSC analysis. The concentration of polymers such as Carbopol 934 (X1) and HPMC K15M (X2) were selected as independent variables. Floating lag time and percentage drug release at 12 hrs were selected as dependent variables. The model was found to be nonlinear and the curvature effect was significant. Hence, the system suggested to central composite design. Results: FT-IR studies demonstrated that there is no considerable interaction between the drug and the excipients. DSC studies revealed that drug and excipient were compatible as there is no significant change in melting point of drug when blended with excipients. The pre compression parameters of the prepared formulations showed good flow properties. The evaluation of post compression parameters indicated that all the prepared formulations were within the specified limits. Floating lag time of prepared formulation were found to be less the 1 min and total floating time of more than 12 hrs. Percentage drug release of all formulations were in the range of 89.7% to 99.4%. The obtained design space/contour plots were used for selecting batches in desirable ranges. Conclusion: The results revealed that experimental design was successfully used to optimize polymer concentrations. It was determined that the central composite design would be used to formulate dextromethorphan gastroretentive floating tablets with less trials and higher superiority features.