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Identifying common dietary substances capable of affording protection or modulating the onset and severity of arthritis may have important human health implications. A eugenol and curcumin fraction isolated from Syzgium aromaticum and Curcuma longa has been shown to possess antiarthritis in experimental animals. In this study, we determined the effect of collagen-induced arthritis in rats. The neutral endopeptidase activity was approximately 7-fold higher in arthritic joints of non-GTP-fed rats than non-arthritic joints of unimmunized rats. In contrast, it was only 2-fold more elevated in the arthritic joints of GTP-fed rats. Additionally, type II collagen-specific levels were lower in serum and arthritic joints of GTP-fed rats. Taken together, our studies suggest that eugenol and curcumin from Syzgium aromaticum and Curcuma longa that is rich in antioxidants may be useful in the prevention of onset and severity of arthritis.