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Brassica nigra is a traditional medicinal plant widely used in the treatment of asthma and rheumatism. The present study evaluated the antiarthritic properties of different doses of developed herbosome formulation and compared them with the plain extract. The herbosome formulation was developed using lipid concentration and cholesterol concentration as independent parameters wherein particle size and percentage entrapment efficiency were the dependent parameters. The developed formulation was evaluated for antiarthritic activity by adjuvant-induced arthritis. The optimized formulation revealed a mean particle size of 320 nm with 0.621 as PDI. The zeta potential values showed a mean of -36.2 mV revealing the stability of the formulation. Herbosomes with a dose of 400 mg/kg significantly decreased primary lesions and secondary lesions in adjuvant-induced arthritis. The findings of this experimental animal study indicate antiarthritic properties of Brassica nigra and thus provide pharmacological support to the traditional use of Brassica nigra in the treatment and management of painful, arthritic inflammatory conditions.