20–21 Jan 2022
Birla Institute of Technology
Asia/Kolkata timezone

Drug repurposing for the prophylaxis of Covid-19: An in-silico approach for antihistaminic drug

Not scheduled
10m
Birla Institute of Technology

Birla Institute of Technology

Mesra, Ranchi 835 215, Jharkhand, India
Poster Presentation Pharmaceutical Chemistry Poster Presentations

Speaker

Tejaswini Selwate (Kamla Nehru College of Pharmacy, Nagpur)

Description

SARS-CoV-2, single-strand RNA viruses known as betacoronavirus in Coronaviridae causing the Covid-19 epidemic with high infectivity and fatality rates. The severity of the epidemic and un-attainability of highly efficacious and specific treatment for SARS-CoV-2, dire need of therapies, researchers are rushing to identify strategies to combat Covid-19 from existing labeled drugs. These already labeled and proven safety drugs can be rapidly repurposed to clinic applications for treating Covid-19 patients. In the current study, efforts were made to repurpose antihistaminic drugs, Cetirizine to combat the Covid-19 infection. The PASS study of cetirizine showed the antiviral activity of the drug. Hence the molecular docking was studied by using AutoDock Vina to find the binding affinity of cetirizine as a ligand molecule towards RDRP as an active site. The RDRP, PDB ID: 6M71, and 6TY8 (viral proteins) were selected as targets. From the docking study, the binding affinity of the drug and target 6M71 & 6TY8 was found to be -7.8 & -6.9 (kcal/mol) respectively. Clinical studies are needed to measure the effectiveness of Cetirizine for disease prevention, for early intervention, or as adjuvant therapy for severe Covid-19.

Primary author

Tejaswini Selwate (Kamla Nehru College of Pharmacy, Nagpur)

Presentation materials