Conveners
Poster Presentations: Session 5
- Ashok Kumar Patnaik (Birla Institute of Technology, Mesra)
- Animesh Ghosh (Birla Institute of Technology, Mesra)
Description
Poster presentation by a registered participant, selected through a peer-review process
Diarrhea is defined as the passage of more watery stools three or more times per day. It is the second leading cause of death in children under five years of old. Loperamide and other antibacterial drugs are usually preferred for treating diarrhea. Loperamide may cause addiction and cardiotoxicity. Phyllanthus amarus S. is traditionally used in treating many health problems such as jaundice,...
The main aim of the present study is to investigate the effects of temperature and exposure time on the extraction of Opuntia ficus-indica and Opuntia dillenii cladodes. Cladodes and other parts of plants were rarely extracted for their constituents from literature. Screening, however, was not conducted to determine the influence of dependent variables on independent responses. The impact...
The Methanolic extract of leaves of Annona squamosa (Linn.) has been tested for their anti-obesity property. The extracts were examined for the presence of phytoconstituents, antioxidant activity, digestive enzyme activity, hypoglycaemic effect, hypophagic effect & histology of adipose tissue, and fatty liver changes by using MSG-HFD induced obesity in Swiss albino mice. Animals treated with...
A simple, effective, and sensitive HPLC with UV detector was developed for detection of these biogenic amines metabolites in the urine sample of rodents as biotargets for neurological diseases like Parkinson’s disease, Alzheimer’s disease, Depression. The method includes the mobile phase combination of acetonitrile (ACN) and o-phosphoric acid (pH 2) in a ratio of (30:70 v/v), pH 2.2; the...
A rapid and stability-indicating Ultra-Performance Liquid Chromatography (UPLC) method was developed for simultaneous quantification of Ibuprofen and Caffeine in their combined dosage form, especially to get some more advantages over other methods already developed for this combination using Photo Diode Array (PDA) detector. The separation was achieved on a UHP ASB C18 column (2.1 mm X 50 mm,...
The market is flooded with a combination of drugs in various dosage forms. Multi-component formulations are in demand due to greater patient acceptability, increased potency, multiple actions, fewer side effects, and quicker relief. Analytical methods are needed to analyze multi-component formulations. Among the instrumental method for analysis, there is a renewed interest in UV...
Design, synthesis, biological evaluation, and in-silico study of imidazopyridine-linked thiazolidinedione promise anticancer agents. A series of imidazopyridine-linked thiazolidinedione rings (6a-h) were synthesized and tested for their antiproliferative activity against a panel of three human cancer cell lines viz., MCF7 (human breast cancer), A549 (human lung cancer), and DU145 (human...
The present work is aimed at designing, synthesizing, and evaluating a library of 2-amino-1,3,4-thiadiazole based compounds as anticancer agents through their inhibitory action against Cyclin-Dependent Kinase (CDK2) enzyme. CDK2 is a member of the protein kinase family, which plays a major role in regulating various events of the eukaryotic cell division cycle. It is overexpressed in cancer...
Rosmarinus officinalis Linn. is an aromatic perennial herb with fragrant evergreen needle-like leaves. It is member species of the Lamiaceae family. It is used commercially for antispasmodic, antimicrobial, anti-inflammatory, analgesic, antipyretic, cardiac tonic, antioxidant, antiapoptotic, anti-tumorigenic, antinociceptive, antiasthmatic, and neuroprotective properties. Our study focuses...
The aim of the present study is to formulate and optimize a tinidazole-loaded transfersomal gel. Transfersomes are formed by self-assembly of non-ionic surfactant and soya lecithin upon hydration with an aqueous medium resulting in a lamellar structure that encapsulates both polar and non-polar drugs. It is also a vesicular carrier for drug delivery systems. In the present research work, we...
Fungal infections have shown great concern with the emergence of a high threat to medically compromised patients with low immune systems, especially Candida albicans, with an increased incidence of resistance. For this reason, there is a need for developing innovative dosage forms. Hence, the main objective of this present investigation was to develop nanofibers of voriconazole using various...
Current research is based on the development and differentiation of transdermal proniosome-based gel. The modified proniosomal gel shows good stability, release, following zero-order kinetics, maximum zeta power is ±49 mV. The pH of the whole composition was close to the skin pH 7.11 to 7.20 the drug content in the formulation was within an estimated range of 92-97%. The composition of the gel...
Osteoarthritis (OA) is a non-communicable disorder of multiple etiologies/origins, estimated to affect more than 500 million people worldwide which is 7% of the world population. while there are no pharmacological interventions other than pain management, understanding the mechanism and intertwined pathways is essential for developing a formulation addressing this multifactorial disorder. We...
There is a growing concern with chronic wounds in the modern medical era because they do not heal through the usual phases in an orderly and timely manner. Bacterial colonization of Staphylococcus aureus is one of the major causes of chronic wounds. Generally, the wound healing process can be potentiated by increased angiogenesis. Oxidative stress also influences wound healing as it mediates...
Asthma is a chronic reversible allergic inflammatory disease of lung airways that affects millions of people worldwide; even then, only symptomatic treatment is given to control asthma. At present, the low dose inhaled corticosteroids are the standard gold treatment for asthma but have many severe side effects. So, this study aimed to search for a natural potent anti-inflammatory therapeutic...
Endocrine disruptor compounds (EDCs) are synthetic or natural molecules in the environment that promote adverse modifications of endogenous hormone regulation in humans and/or in animals. By interfering with the body’s endocrine system, these chemicals produce adverse developmental, reproductive, neurological, and immune effects in animals, abnormal growth patterns, and neurodevelopmental...
To develop a simple, accurate, precise, and economical method for the simultaneous estimation of the Lamivudine and Dolutegravir in pharmaceutical dosage form by ultra-performance liquid chromatography (UPLC) using tunable ultraviolet (TUV) detector. The separation was achieved on an HSS C18 column (2.6 mm X 50 mm, 1.6 µm,) at a wavelength of 260 nm, using a mobile phase disodium hydrogen...
The present work is aimed to investigate the effect of ethanolic extract of fruit pulp of Annona squamosa against aluminium chloride-induced Alzheimer’s disease. Male Wistar rats were selected in this study and were divided into five groups (6 each). Group, I served as standard control. Group II received aluminium chloride (17 mg/kg, P.O.). Group III received rivastigmine (0.3 mg/kg, I.P.)...
Herbal transdermal patches can develop valuable assessment and drug safety by additional site-specific the way and temporal position in the body’s imperative to reduce the number and size of doses required to achieve the objective of systemic medication during topical application to the intact skin surface. Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease of unknown...
Cancer is the second leading cause of death globally after heart disease, and unfortunately, its incidence is rapidly growing. Thiazole derivatives are currently one of the most frequently studied compounds in anticancer drug discovery due to the easy optimization of the structure and the ability to synthesize a wide group of derivatives. Therefore, discovering new drugs with very high...
Apple cider vinegar (ACV) is one of the most widely used condiments for various pharmacological activities. The area of ACV research is a multi-dimensional and interdisciplinary research domain. The recent research works showed that ACV is not only beneficial for weight loss, antibacterial, antifungal, cardiovascular activity but also it has anti-cancer, anti-Alzheimer’s activity. Although...
A new simple, accurate, and economical reverse-phase high-performance liquid chromatographic method was developed for the estimation of Tolterodine in bulk and tablet dosage form. The separation was eluted on Agilent TC C18 column (250 mm x 4.6 mm; 5 μm) using a mobile phase mixture of 0.1% orthophosphoric acid and methanol in a ratio of 50:50 v/v at a flow rate of 1.2 mL/min. The detection...
Skin diseases, especially Leucoderma (or) Vitiligo, is an important widespread disease all over the world. Vitiligo is a skin condition characterized by “White patches resulting from the loss of pigment. Cleome chelidonii Linn. is a traditional plant belonging to the family Capparaceae. It is grown as perennials throughout dry seasons. It has pink rose (or) white color flowers. (Tamil...
Epilepsy is one of the most common serious neurological disorders, responsible for substantial morbidity and mortality due to the limited efficacy and negative properties of antiepileptic drugs. Epilepsy treatment is based on the use of drugs that aim to inhibit repetitive neuronal discharges, and consequently, the recurrence of seizures. However, despite the large number of antiepileptic...
In this present research work, we have designed a suppositories formulation by applying a quality by design approach. We have successfully developed suppositories of mefenamic acid to meet the optimized requirement of our suppository formulation. Our main aim was to develop suppositories to target mefenamic acid via the rectal route. The fusion and molding method was used to prepare...
This research project aimed to design and synthesize hydrazide schiff base derivatives as an antimicrobial agent. Thus the objective was to perform in-silico studies of the designed compounds, synthesize, accomplish spectral analyses, and assess in-vitro antimicrobial activity. In-silico physicochemical properties using Molinspiration Cheminformatics software and computational toxicity studies...
In the recent era of research and development, silver nanoparticles (AgNPs) are the most attractive nanomaterial in the development of nanomedicines due to their specific and distinctive physiochemical properties. Nanotechnology deals with the Nanoparticles having a size of 1-100 nm in one dimension used significantly concerning medical chemistry, atomic physics, and all other known fields....
This study investigated the utility of chemically modified xanthan gum (XG) for controlled drug delivery of Lornoxicam. Lornoxicam belongs to an oxicam class of nonsteroidal anti-inflammatory drugs. It inhibits the cyclooxygenase enzyme and thereby interferes with prostaglandins synthesis. Chemical modification of xanthan gum was carried out by using a thiol-esterification reaction employing...
Covid-19 vaccination drives are rolling out globally. However, there is a need to identify effective treatment on SARS-CoV-2 and its non-synonym variants. In pandemic urgency, discovering a new drug is impossible considering the time scale and attrition rate. Thus, the concept of repurposing labeled or already approved drugs to treat Covid-19 would be a logical choice for new drug development...
To determine the comparative studies of analytical methods for simultaneous estimation of drug Meropenem and Sulbactam sodium in bulk and parenteral preparation. Literature survey reveals that techniques have been developed to estimate Meropenem and Sulbactam sodium individually. No method has been reported to evaluate Meropenem and Sulbactam sodium in combined form. Hence the above...
We start with a short historical perspective of computational approaches in analytical research and development and discuss its current feature set. In contrast, during the development of a new chemical entity, the computational tools might be plays an important role and primed up growth. The enhancement of research and developments by the route of new or existing computational approaches...
PIM kinases are members of the class of kinase family serine/ threonine kinases, which play a crucial role in cancer development. As there is no drug in the market against PIM-1, kinase has transpired as a budding and captivating target for discovering new anticancer agents targeting PIM-1 kinase. The current research pondered the development of new PIM-1 kinase inhibitors by applying a...
Catechins, an herbal polyphenolic flavonoid found in green tea, have received considerable attention due to their favorable biological properties, including cardioprotective, neuroprotective, and anti-cancer effects. The aim of the present work is to develop biodegradable polymeric nanoparticles based oral drug delivery for encapsulation and controlled release of polyphenol compound Catechin....
Tea tree oil is a yellow liquid extracted from Melaleuca alternifolia. It has an excellent antibacterial, antifungal, anti-inflammatory activity, which is used topically in niosomal gel for bacterial infection. Tea Tree oil-loaded noisome was prepared by thin-film hydration technique. Nine different batches are prepared by changing cholesterol: span 60 ratios, hydrating speed, and hydrating...
The aim of this work was to design a small molecule inhibitor of CYP1B1 enzyme by computational approach and performing synthesis and biological evaluation of a small library of synthesized molecules. Selective inhibitors of CYP isoforms are important in the treatment of cancers caused by hormonal imbalance. This could avoid the severe mechanism-based toxicities or off-target effect as CYP1B1...
Dengue has continued to affect most of the nations of the tropical and subtropical regions of the world, it has in no way given respite in the Covid era too as cases seem to be on the rise in the year 2020 and 2021. The pandemic period has imposed a significant strain on all nations’ medical infrastructure, and the emergence of dengue and the possibility of a dengue-Covid co-infection adds to...
The research work deals with the design, synthesis, and characterization of a series of 6substituted-4-hydroxy-1-(2-substituted thiazole-4-yl)-quinoline-2(1H)-one derivative [III(a-d)(1-3)] and evaluation of their in vitro anticancer activity against MDA-MB (Breast cancer) and A549 (Lung cancer) cell lines. A series of substituted thiazole-4-yl-quinolin-2(1H)-one derivative [III(a-d)(1-3)]...
The current investigation aimed to design, synthesize, and characterize novel anti-inflammatory drugs for superior action and reduce concomitant effects. Novel disubstituted metal complex compounds of 2-(1, 3-dioxoisoindolin-2-yl) acetic acid derivatives were designed, synthesized, characterized. The compounds were synthesized through amide intermediates. Virtual screening of synthesized...
Monoamine oxidase A and B (MAO-A/B) are FAD-containing enzymes found in the outer mitochondrial membrane and are responsible for the oxidative deamination of biogenic monoamines. The tissue distribution of MAO-B is more (80%) in the brain. The high concentration of MAO-B in the brain decreases dopamine level and increase oxidative stress. On the other hand, acetylcholinesterase (AChE)...
With reference to our previously reported work on imidazoles, herein our objectives are to report the molecular docking studies of the synthesized imidazole analogs 2(a-f) into the non-nucleoside inhibitory binding pocket (NNIBP) of HIV-1-reverse transcriptase (PDB ID: 1RT2). The methodology consisted of the drawing of the chemical structures in Chem Office version 15.0.0.106 and the docking...
In the last few decades, it has been observed that the diabetes population is increasing around the world. Apart from insulin injections, various oral antihyperglycemic medications are available, like sitagliptin, to increase insulin production to control diabetic conditions. But sitagliptin has a very short biological half-life of 8-14 h, and only 38% drug binds to plasma protein; also, 79%...
Helicobacter Pylori (H. pylori) is a common bacterium it causes gastritis and peptic ulcer disease. It affects half of the world’s population. The purpose of the research work has been to develop levofloxacin hemihydrate-loaded mucoadhesive alginate beads to treat H. pylori infection. Formulations were prepared by ion gelation method using various concentrations of sodium alginate,...
The study aims to develop and optimize eberconazole (EBZ) loaded niosomes using Central-Composite Design and their preliminary evaluations. EBZ loaded niosomes were developed using ether injection method containing gelucire 48/16 (Nonionic surfactant) and cholesterol as an additive agent. These formulations were statistically optimized using the Central composite experimental design. Leica...
A simple, sensitive, rapid, reliable, and economic RP-HPLC method was developed & validated for simultaneous estimation of Telmisartan and gallic acid in bulk and a pharmaceutical dosage form. One of the prominent causes of hypertension is oxidative stress produced by reactive oxygen species. Gallic acid is a polyphenolic drug, having a very good antioxidative property that reduces oxidative...
The aim here is to optimize and characterize the chitosan-coated nanoparticles of Forskolin and Rutin for ocular delivery for the treatment of glaucoma. Forskolin and Rutin nanoparticles coated with chitosan were prepared by the emulsion solvent evaporation method. A four-factor three-level Box-Behneken design was used to investigate the influence of independent variables on particle size and...
SARS-CoV-2, single-strand RNA viruses known as betacoronavirus in Coronaviridae causing the Covid-19 epidemic with high infectivity and fatality rates. The severity of the epidemic and un-attainability of highly efficacious and specific treatment for SARS-CoV-2, dire need of therapies, researchers are rushing to identify strategies to combat Covid-19 from existing labeled drugs. These already...
Helminthiasis, also known as worm infection, is any macroparasitic disease of humans and other animals in which a part of the body is infected with parasitic worms, known as helminths. There are numerous species of these parasites, which are broadly classified into tapeworms, flukes, and roundworms. Acalypha indica is a medicinal plant that is widely used in traditional medicine to treat...
Identifying common dietary substances capable of affording protection or modulating the onset and severity of arthritis may have important human health implications. A eugenol and curcumin fraction isolated from Syzgium aromaticum and Curcuma longa has been shown to possess antiarthritis in experimental animals. In this study, we determined the effect of collagen-induced arthritis in rats....
The liver plays a crucial role in the metabolic elimination of most drugs and other foreign compounds, thus making it an important target for toxicity. The hepatotoxic response is expressed in the characteristic form of cell death in specific zones of acinar regions in the liver. Keeping the above perspectives in mind, the herb, RV forte (resveratrol-based formulation) capsules, and TCCT...
Among all side effects seen, those associated with the effects of anticancer therapy on the bone marrow (BM) represent a potentially dangerous and even life-threatening circumstance. Because most anticancer treatments affect rapidly dividing cells preferentially, BM is an ideal target for these effects. This is the primary reason that myelosuppression is among the complications most frequently...
Anti-tubercular drugs (ATD) are the leading cause of drug-induced acute liver failure in India. The most effective first-line antitubercular drugs (ATD), Isoniazid (INH), and Rifampicin (RIF) have been used to treat tuberculosis (TB). The majority of potent ATDs, including INH, RIF, and Pyrazinamide, are hepatotoxic. When these medications are used together, the risk of hepatotoxicity...
Excessive exposure to UV rays causes hyperpigmentation, premature aging, and skin cancer. Due to these harmful effects of UV radiation, there is a need to develop sunscreen formulations to heal and prevent sunburn and increase the level of protection from the UV rays. Flavonoids and phenolic compounds have a good capacity to absorb UV rays in UV-A region and possess good antioxidant activity....
Fast dissolving oral films are drug delivery systems of the new day having one of the highest patient compliance, safety & are economical than most other dosage forms. Hydrophilic polymers, when in contact with water, get hydrated and thus show drug release if used as a vehicle. Hydrophilic polymers also show an adherence property post hydration. Thus the hydrating and adhering properties of...
Medicinal plants are an important source for the development of antifungal agents. The objective of the present study was to develop an antifungal emulgel using Calotropis gigantea latex extract. Emulgel comes to favor the hydrophobic drugs to give the advantage of gel. Emulgel has several advantages in the field of dermatology such as being thixotropic, greaseless, easily spreadable, easily...
More than 80% of peptic ulcer diseases are caused by H. pylori infection. The purpose of the study was to formulate and evaluate the floating microspheres of Levofloxacin hemihydrate to treat H.pylori infection. The floating microspheres of Levofloxacin hemihydrate were prepared by emulsion solvent diffusion technique using HPMC K100M, EC used as polymers. SEM, drug entrapment efficiency...
Helicobacter pylori (H. pylori) infection is a common worldwide infection and an important cause of peptic ulcer disease and gastric cancer. The purpose of the study was to prepare levofloxacin (LVF) floating tablets for Helicobacter pylori eradication. Floating tablets of Levofloxacin were prepared by direct compression using different hydrocolloid polymers such as hydroxypropyl...
The study was conducted to develop a gastro-retentive tablet of carvedilol by raft forming system for the treatment of hypertension. It was achieved by the formulation of carvedilol tablets using different polymers in variable ratios. The raft drug delivery provides drug delivery for more than eighteen hours by forming a gel-like structure. Preparation of gastro retentive tablet using raft...
About 70% of the population suffers from dental problems. Oral antimicrobial agents are used to treat the infections occurred in the periodontal cavity. The objective of the presented study was to reduce the frequency of Doxycycline administration and to prolong the duration of action for better patient compliance in periodontitis by formulating a temperature-sensitive oral in situ gelling...
The present study is concerned with the formulation and optimization of famotidine mucoadhesive tablets by using a central composite design. The concentrations of Cordia dichotoma dried mucilage powder (X1) and PVP (X2) were selected as independent variables. In-vitro mucoadhesion time and percentage drug release were selected as dependent variables. The model was found to be nonlinear and the...
Otitis media is a middle ear infection that clears within a week but requires repeated administration of the drug. Topical available marketed solution when instilled, rapidly eliminated from ear cavity if the patient had not kept the head inclined. To overcome the issues related to the conventional drop, in the presented study, Levofloxacin hemihydrate was incorporated in a poloxamer-based...
Amorphous solid dispersions (ASDs) are aimed to improve the solubility of poorly water-soluble drugs. The purpose of the present study was to determine the technique which provided maximum solubility of ASD of Diclofenac sodium with suitable polymer and buffer media. ASDs can be prepared using various methods. In this experiment, ASDs of BCS Class 2 drug Diclofenac sodium were prepared using...
Azadiracta indicia is an herbal medicine which is used for various ailments. We have made efforts to bring a new formulation of toothpaste with more stable in terms of rheological behavior, long-term protection and stability in diverse conditions. The aim of the present study is the formulation of new herbal toothpaste and its evaluations along with stability studies. The plant *Azadiracta...
This study aims to design and evaluate oral sustained release matrix tablets of BCS class 2 anti-anginal drug using Eudragit L 100-55 as the retardant polymer and mannitol as a channeling agent for the delivery of anti-anginal drug as twice-daily dose. The tablets were made using the traditional wet granulation approach. Weight variation, hardness, friability, and drug content were all...
One of the primary goals behind our present work is to improve further the acetylcholinesterase (AChE) inhibition property of compound 2e. The main objective of this study is to carry out further modification on the phenolic OH group of ferulic acid (FA) to improve upon the AChE inhibition activity without compromising antioxidant properties for the management of AD. We rationally selected 2e...
Nanotechnology has been recognized as one of the sprouting inter-disciplinary research fields. Silver nanoparticle (AgNP) has gained increased attention due to their unique properties and multifaceted applications. The development of resistance of bacteria to antibiotics is becoming an area of concern which has led to renewed interests in investigating the potency of AgNP. Green chemistry...
In recent decades the healthcare expand lots in disease diagnosis and their treatments will with the help of different traditional and conventional ways but due to many limitations they are not applied in the gastroretentive drug delivery system because they don’t have good gastric residence time so to overcome such problems we move on these gastroretentive drug delivery system which has...
Zandu haldi drops is a one-of-a-kind recipe designed to improve immunity and overall health. It contains the goodness of saffron, cinnamon, cardamom, and black pepper, in addition to Haldi. Hence, the present work was aimed at the determination of haldi (turmeric) in Haldi drops by high-performance thin layer chromatography (HPTLC) with reference to the marker compound curcumin. The standard...
Focal adhesion kinase (FAK), a protein tyrosine kinase, has been overexpressed in cancer cells and plays a pivotal role in the proliferation of tumor malignancy. There is no FDA-approved and marketed the drug as FAK inhibitor for clinical use by far. This calls for a dire need to advance an area of active FAK inhibitors as possible anticancer entities. In the present study, applying...
Self micro-emulsifying drug delivery system (SMEDDS) is a transparent, physically stable micro-emulsion with a droplet size of less than 50 nm. In the presented study, solubility of bosentan monohydrate (BM) was improved by formulating SMEDDS using oils, surfactant, co-surfactant and to improve the stability; the optimized formulation was converted into a solid dosage form. Initially, the...
Out of the various therapeutic targets available for diabetes mellitus (DM), dipeptidyl peptidase4 (DPP-4) inhibitors are found to be the safest, effective, and tolerable target. They act naturally to control blood glucose levels and improve nephropathy, retinopathy, and cardiovascular complications. Some phytoconstituents such as cirsmaritin (IC$_{50}$ = 0.43±0.07 μM), hispidulin (IC$_{50}$ =...
Benzimidazole, a fused heterocycle bearing benzene and imidazole, has gained considerable attention from medicinal chemists worldwide. The moiety is of substantial importance because of its wide array of pharmacological activities, including but not limited to antibacterial, antifungal, anticancer, anti-inflammatory, analgesic, antimalarial, and antitubercular activity, etc. Considering the...
Heterocyclic compounds containing the five-membered oxadiazole nucleus have a diversity of beneficial biological effects, substituted 1,3,4-oxadiazole moieties possess exciting activities such as analgesic, antimicrobial, antitubercular, anticonvulsant, and anti-hepatitis B viral activities. The main objective of this work is to report the study of a series of substituted 1,3,5-oxadiazole...
Benzotriazole is a heterocyclic molecule that has many biological actions such as antibacterial, antifungal, anticancer, anti-inflammatory, analgesic, antimalarial, and antitubercular activity. The objective of this work is to report the study of a series of designed benzotriazole derivatives that have been examined for their molecular docking in the non-nucleoside inhibitory binding pocket...
Fibroblast growth factor receptor (FGFR) plays a vital role in tissue regeneration, angiogenesis, and embryogenesis. 3D-QSAR and molecular docking methods are widely used to design new compounds to determine inhibitory activity against the biological target. In the present study, 3D-QSAR (CoMFA and CoMSIA) and molecular docking analysis were performed on 1,6-naphthyridines and...
Chemical stability of pharmaceutical molecules is a matter of great concern as it affects the safety and efficacy of the drug product. Some degradation products and impurities may even have toxic effects. Therefore, it is very important to develop proper stability indicating method for Melatonin which possibly be used for stability testing and routine analysis. A rapid, sensitive with...
Alzheimer’s disease (AD) is a neurodegenerative disorder. Currently, more than 50 million people are suffering from dementia worldwide. Neuropathologically it is characterized by the presence of extracellular Amyloid β (Aβ) plaques and intracellular neurofibrillary Tau protein tangles in the brain. Literature reveals that a crucial target to relieve symptoms of AD is Acetylcholinesterase...
Presented work was aimed for optimization of poly (D,L-lactide-co-glycolide) PLGA based microsphere formulation for schizophrenia which provides 15 days sustained release for antipsychotic drug. The parenteral intramuscular route is the most preferable route of administration for efficient delivery of active substances with poor bioavailability and with a narrow therapeutic index....
Major depression is a common long-lasting or recurrent psychiatric disease with high lifetime prevalence and high incidence of suicide. It is the second leading cause of morbidity and also leads to suicide. Depression has a cluster of distinguishable symptoms, including psychological, behavioral, and physical changes that are seen due to alterations in monoamines, i.e., norepinephrine and...
The increasing number of antibiotic-resistant bacteria necessitates the development of natural antimicrobial substances with minimal health risks. Medicinal plants’ antimicrobial effects are becoming more well known around the world. Mangroves are biochemically distinctive in that they create a wide range of novel natural compounds, including steroids, triterpenes, saponins, flavonoids,...
Memecylon umellatum Burm. (Synonym. Memecylon edule) belongs to the family Melastomataceae. It is a larges ornamental shrub or small tree found in the coastal region of deccan peninsula and eastern parts of India. The leaves of Memecylon umbellatum have been used traditionally to treat various infection and inflammatory conditions. The plant is the richest source of flavonoids and...
Since time immemorial, nature has always been kind enough towards humanity to provide a plethora of natural resources that have always benefited humans. Most of the currently employed therapeutic agents are derived from natural sources, i.e., plants, animals, and other natural resources. Flaxseed or linseed (Linum usitatissimum L.) is one such annual herb that has contributed enormously to...
The present investigation develops controlled release matrix type transdermal patches of diltiazem hydrochloride using natural and biodegradable polymer hydroxyl propyl methylcellulose. Any type of formulation that allows a drug substance to transit from outside of the skin through the layers of skin to underlying tissues and finally into the systemic circulation to exert a pharmacological...
The literature review reveals that soyalecithin is used as a lubricant and increases poorly soluble drugs' solubility. The present investigation was undertaken to prepare a glibenclamide tablet using soyalecithin as a lubricant and a solubility enhancer. Microcrystalline cellulose is added as disintegrant—magnesium stearate, a lubricant. Pre and post-compression studies were compared....
The outbreak of the novel coronavirus disease (Covid-19) emerged in December 2019; from (Wuhan) China has now become an emergency of major international concern. It is a highly contagious disease that is believed to be a mutated form of SARS (2002) and MERS (2012) virus, causing approximately 3.7% mortality rate worldwide. The main cause of mortality is clusters of severe respiratory illness...
Brassica nigra is a traditional medicinal plant widely used in the treatment of asthma and rheumatism. The present study evaluated the antiarthritic properties of different doses of developed herbosome formulation and compared them with the plain extract. The herbosome formulation was developed using lipid concentration and cholesterol concentration as independent parameters wherein particle...
The Nipah virus, a paramyxovirus with Pteropus bats as its animal reservoir, was initially detected in a significant outbreak of severe encephalitis in Malaysia in 1998 among people who came into contact with ill pigs. Humans are already sensitive to the Nipah virus; many strains are capable of limited person-to-person transmission, and, as an RNA virus, it has an extraordinarily high rate of...
A simple, precise, and rapid reverse phase HPLC- SPD 20-A method has been developed and validated to simultaneously estimate Levosulpiride (LEVO) and Pantoprazole (PANTO) in a capsule dosage form. The mixture of LEVO and PANTO was separated on a C18 column (4.6 × 250 mm) using phosphate buffer: methanol (50:50) and pH seven adjusted with dilute orthophosphoric acid a mobile phase. All...
Soil ecotoxicological test is an essential tool for risk assessment of various xenobiotic chemicals. Such tests can be performed using soil invertebrates by exposing them to specified soil contaminating chemicals. Soil invertebrates provide various ecosystem services (i.e., soil transformations are beneficial for mankind). For example, soil invertebrates may influence the mineralization of...
Tuberculosis was a major public health problem and highly prevalent in India. The treatment of tuberculosis is becoming more challenging; it requires accurate and early diagnosis, screening of drug resistance, and effective directly observed therapy and short course. Metal complexes are already in clinical use and encourage further studies for new metallodrugs in the treatment of tuberculosis....
The recent upsurge of viral infections due to viruses such as Ebola, Chikungunya, Zika, Nipah, SARS-CoV-2 led to global distress that drove the focal point on the development of promising antiviral molecules. We have centered our research mainly on the development of potential molecules against Chikungunya which outbreaks into a severe epidemic. Although there is no definite treatment, studies...
Papain enzyme possesses wound healing, anti-inflammatory, and anti-fungal activity. Chitosan has topical wound healing activity, and its activity would be improved when combined with papain enzyme. In the presented study, the chitosan hydrogel containing papain was prepared and applied to wounded skin to check its anti-inflammatory activity. The hydrogel was prepared using chitosan in variable...
Sansevieria cylindrica (SC) and Plumeria obtusa (PO) plants have been investigated for diverse pharmacological activities, but the safety and/or mechanism of toxicity is still lacking in the literature. Subacute toxicity studies will add value to the drug's pharmacological profile. The dose of drugs for this study was decided by limit test. The present study evaluated the toxic potential...
Drug design and discovery in the modern era necessitates rapid and co-optimization of multiple parameters. The quality and quantity of data for drug discovery should be more predictive and accurate for respective models. There should be a holistic approach to improvise the several parameters required in drug design and discovery. Drug design approaches have been categorized broadly as rational...
A thiazolidinedione (TZD), also known as a glitazone, is a five-membered carbon ring molecule commonly used to treat Type 2 diabetes and insulin resistance. There have also been numerous prospective studies that have confirmed these compounds’ anti-proliferative efficacy, despite side effects such as hepatotoxicity, water retention, and cardiac complications. We have synthesized 12 new TZD...
In the present study, 3, 4-dichloroacetophenone on condensation with different aromatic aldehydes in aqueous ethanolic solution yield corresponding chalcones. These chalcones react with phenylhydrazine obtained,1, 3, 5-triaryl-2-pyrazoline derivatives. All the prepared compounds were characterized by IR, NMR spectral data, and elemental analysis. The synthesized compounds screened for various...
Metal complexes of organic compounds are being widely studied for various pharmacological activities, especially as anticancer and antimicrobial agents. Schiff bases are very good ligands that can readily form complexes with various metals like Pt, Ru, Au, Ag, Fe, Co, Cu, etc. Cinnamaldehyde is reported to possess anticancer and antimicrobial activities. Thiazoles form a part of drugs like...
DHPM scaffold were reported to exhibit versatile biological activities. These derivatives possess antimicrobial property which reviewed from the literature. These is a very few study carried out on azo coupled dihydropyrimidinones. So the study focused towards the synthesis of azo coupled DHPMs and the synthesized compounds evaluated for antifungal actions against A. flavus. Synthesis of...
Zandu haldi drops a one-of-a-kind recipe designed to improve immunity and overall health. It contains the goodness of saffron, cinnamon, cardamom, and black pepper, in addition to haldi. Hence, the present work aimed to determine black pepper in haldi drops by UV spectroscopy with reference to the marker compound piperine. The standard curve was prepared by weighing accurately 1 mg of piperine...