The Indian pharmaceutical industry is rapidly growing (expected @ 10-11%). Mny of these companies are seeking market authoirzation in North America, Europe, etc. or are contract manufacturing organizations and exporting to these counrtries. To gain from this momentum the talent pool should have relevant scientific knowledge tht will be useful for the Pharma Industry. This is where Pharmacy...
Prion disease is a fatal, incurable neurodegenerative disease of humans and other mammals caused by conversion of cellular prion protein (PrPc) into a self-propagating neurotoxic conformer (PrPSc). The most prevalent instance of prion disease, also known as human prion disease, is Creutzfeldt-Jakob disease (CJD). It is a rare, contagious neurodegenerative disorder involves epigenetic...
A Review Article on Hyperlipidemia: Types, Treatments and New Drug Targets
Adrija Sarkar*, Ashok Pattnaik
Department of Pharmaceutical Sciences & Technology,
Birla Institute of Technology, Mesra,
Ranchi, Jharkhand, India, 835215
Email: [email protected]
Abstract:
Hyperlipidemia is a medical condition characterized by an increase in one or more of the plasma lipids, including...
The main haemoglobin that forms during the gestation period is Fetal Haemoglobin(HbF). But this globin chain is replaced and is taken over by adult haemoglobin. Sometimes this switch from fetal to adult fails to occur leading to production of HbF as in case of sickle cell anaemia. It is also observed that HbF expression is also seen under malignant condition, in DNA methylation, HbF inducing...
Aim
To unveil the molecular targets of gallbladder cancer and their natural drug candidates
Background
Gallbladder cancer (GBC) is one of the most aggressive malignancies of gastrointestinal tract and its treatment remains a challenge. Because of the side-effects and resistance to existing chemotherapies, exploring the natural alternatives has become crucial. Previous in-vitro studies...
Since the past several decades, poor water solubility of existing and new drugs in the pipeline has remained a challenging issue for the pharmaceutical industry. These compounds have high therapeutic potential but are difficult to formulate as oral dosage forms due to their poor aqueous solubility. The use of conventional approaches such as solubilizing agents, salt formation, complexing...
Abstract:
Aim: A simple, sensitive, rapid, reliable, and cost-effective HPTLC method for simultaneous estimation of "Amlodipine" and "Moxonidine" in bulk and pharmaceutical dosage form was developed and validated. Since combined drug formulations are so important in medical science these days, it is critical to standardize the product using modern analytical techniques.
Methodology: This...
Most of the new chemical entities (NCEs) that are being developed suffers from poor physicochemical properties like low solubility, low permeability which in turn results in poor and erratic bioavailability. In order to improve the poor physicochemical properties of the active pharmaceutical ingredients (API’s), various approaches like salt formation, particle size reduction, the addition of...
The science of nanotechnology has seen incredible progress in the recent years and has opened up new avenues of possibilities in the field of engineering, biomedical science, drug-delivery, chemical industry and environmental research process. In this regard, ‘green’ synthesis has gained widespread attention as a reliable, sustainable, non-toxic, economical and eco-friendly alternative for...
Today, the whole world is facing the problem of resistant microbial infections, wherein, tuberculosis (TB) is not the exception. TB has drastically been observed for resistant infections such as multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) infections. In present study, we have synthesized 10 new hydrazones using greener and eco-friendly synthesis using...
Environmental pollution is a concerning risk factor for worldwide morbidity and mortality as it has a unique connection with respiratory diseases. Gaseous pollutants like nitrogen dioxide, sulphur dioxide, carbon monoxide and other particulate matter majorly contribute to the environmental pollution. Cigarette smoke constitutes these gaseous pollutants and affects both active and passive...
In recent times have seen the term "obesity" used to describe a condition where a person has turned into a diseased vessel. Because it resembles the pathology of fatal diseases, the internal pathology of obesity is too mysterious. Numerous organizations have declared a simultaneous epidemic of obesity and the coronavirus disease of 2019 (COVID-19) after observing their escalation in the recent...
Tetracyclic triterpenoids called cucurbitacins, which are very oxidized compounds, are commonly used in traditional Chinese cures(Cucurbitaceae family), have potent antineoplastic activity. Cucurbitacins have more than 200 types of cucurbitacins derivatives. Cucurbitacin has 30 carbon skeleton which is a cucurbitane kind of saponin that is tetracyclic ring. Alphabetically from A to T...
Abstract
To date, wound healing remains a challenging clinical process due to its multifaceted process occurring in four phases: hemostasis, inflammation, proliferation, and remodeling. Persistence of any of these stages leads to delayed or untimely healing of wounds or relapse, commonly known as chronic wounds. There are several concurrent diseases that prevent the...
Holi colours (gulal) have been used traditionally in India for several years. Due to recent trends, gulal has reached the international market in Europe and the USA. These mesmerizing colours have found their use for both religious and entertainment purposes. Despite having a surge of demand in the market, the labeling of the ingredients is not clear. Often times there is no scientific...
Drug and its Chirality: Therapeutic Correlation
Shweta1, Ghosh Manik*1
1Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology,
Mesra, Ranchi, Jharkhand, 835215, INDIA
[email protected]
ABSTRACT
The potency, pharmacological activity, metabolism, plasma disposition, toxicity, and excretion kinetics of an isomer of a physiologically active molecule might...
Breast cancer became the world’s most prevalent cancer surpassing lung cancer and presented great challenges because of the unavailability of effective treatment strategy. Hence, a gene therapy-based cancer treatment strategy can offer the privilege of more targeting accuracy and fewer side effects. In this technique, small fragments of oligonucleotides (non-coding RNAs such as miRNA, siRNA...
In the modern world, dementia is a major age-related neurodegenerative disorder, which has been encountered by around 55 million people with a sharp increase of 10 million new cases each passing year. This neurological issue is mainly occurred due to the generation of reactive oxygen species, formation of beta-amyloid plaque, decrease in acetylcholine or overproduction of acetylcholine...
Microsponges have become research of interest in the recent times due to its extremely porous matrix, non-collapsible nature, highly cross-linked structure, improved stability, high drug entrapment efficiency, and controlled drug release. Verbascoside is a water soluble phenylpropanoid glycoside which have shown potential antimicrobial activity. The present study is designed to formulate the...
In diabetic patients delayed wound healing and chronic wounds are major complications that have been a reason of serious concern. A decrease in the proliferation and migration of different cells like keratinocytes and fibroblasts are considered to be the major reason behind the development of such wounds. Thereby, designing a wound dressing patch using a biodegradable hydrogel which can...
Since several decades, our healthcare burden has been increased due to tremendous cases of multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) infections, especially in tropical countries. In the present study, we have synthesized ten hydrazides with the use of the greener Chitosan-derived catalyst. This catalyst accomplished the said condensation reaction within...
Abstract:
Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained considerable attention of medicinal chemists throughout the world. The moiety is of substantial importance because of its wide array of pharmacological activities including but not limited to antibacterial, antifungal, anticancer, anti-inflammatory, analgesic, antimalarial, and antitubercular activity, etc....
The WHO database shows that Mycobacterium tuberculosis has become an epidemic worldwide due to its pathogenicity and virulence, which have magnified its infectiousness. The situation becomes grimmer with the prevalence of MDR-TB, XDR-TB, emergence of cross-resistance, ineffectiveness of novel therapeutic targets, failure of novel medications in clinical trials, currently available drugs losing...
Hydrogels have become a formulation of interest in recent years due to their biodegradability, compatibility with natural tissue, and controlled drug release. The formation of a polymeric network-like arrangement within the gel matrix which is water-swellable in nature allows efficient entrapment and release of active ingredients. Clerodendrum glandulosum (CG) has been reported to have...
Wound healing has gotten a lot of attention in recent years. Immunological diseases, such as diabetes, cause complications that can lead to death. There are few wound care medications and formulations available. In this study, Grewia asiatica linn. leaves extract was tested for wound healing activities in a series of in vitro and in vivo studies. This includes phytochemical screening to...
Acquired Immunodeficiency Syndrome (AIDS) is caused by Human Immunodeficiency viruses, which consist of two species of lentivirus (a subgroup of retrovirus). AIDS is a condition in humans in which progressive failure of the immune system allows life threatening opportunistic infections and cancers to thrive. Without treatment, the average survival time after infection with HIV is estimated to...
Cardiovascular diseases are the main cause of mortality worldwide and hypertension is one of the major cause that is find to be in continuous relationship in precipitating disease. Hypertension is a chronic elevation of blood pressure,that causes serious damage to renal, cerebral, and vascular system. It has been estimated that around 1.28 billion people worldwide have been found to suffer...
Niosomes are nonionic surfactant vesicles that help in the effective delivery of both hydrophilic & hydrophobic drugs by incorporating them within their inner aqueous core and outer lipophilic layer, respectively. Its nonionic character help in providing the non-toxic and nonimmunogenic character, while its surfactant nature helps enhance the solubility of the poorly soluble drug (BCS Class II...
In the last decade, various research work and review articles are being reported showing the importance of niosomes and their advantages over the other vesicular formulations. Niosomes are vesicular structure that is made up of non-ionic surfactant, cholesterol, and sometimes charged inducers. The non-ionic surfactants assemble among themselves to form the bilayer vesicular structure. The...
GOLDEN JUBILEE CELEBRATION 2022
POSTER COMPETITION
BIT MESRA
NOVEL BIOTHERAPEUTIC APPROACH IN COMBATING RESURRECTION OF COVID-19 Purnima Mahto, Deepika Kumari, Monika Dwivedi (Corresponding Author)
In the last two decades, many viruses have caused disease outbreaks in various parts of the world. That also includes SARS coronavirus (SARS-CoV) which was reported epidemic in 2002–2003....
Context and Rationale: Quercetin (QCE), a flavonoid found in foods, is a member of the polyphenol family and is derived mainly from plant and fruit sources. QCE is a natural antioxidant that suppresses the excessive generation of reactive oxygen species (ROS) inside the cellular microenvironment. Therefore, it may treat various medical conditions, including cancer, infections,...
Dosage forms of drug contain various excipients along with Active Pharmaceutical Ingredient (API) to make a complete dosage form and assist in manufacturing process. Advancement in drug delivery technology led to use of these excipients in novel dosage form to fulfil the criteria of specific functions like extent and/or rate of drug release and absorption. As plant polysaccharides comply with...
Abstract: Alzheimer’s disease (AD) is a neurodegenerative old aged, unalterable, complex and progressive disease in nature which causes around 70% of dementia cases in worldwide. According to WHO, around 55 million people are currently suffering with Alzheimer’s disease throughout the world. The presently approved therapies like cholinesterase inhibitors, NMDA receptor antagonists provide only...
The onset of the 21st Century saw humanity witness a sudden rise in life expectancy with modern medical science being at the forefront of this change. Diseases once untreatable, are eradicated in a blink of an eye. A visible transition of people prioritizing modern dosage forms like tablets, capsules, syrups, creams, ointments, etc. rather than their trusty ayurvedic counterparts like...
Abstract
Tissue engineering is the discipline that deals with the regeneration of damaged tissues. Nanofibers are the most acceptable substances for the regeneration of tissues because it mimics the Extracellular cellular matrix (ECM), so the cells can easily proliferate on it. Natural polysaccharides are used for the development of nanofibers because of their biocompatibility and...
Abstract:
Breast cancer is the most widespread cancer and leading cause of death among women and very rarely in men. This constitutes the second most frequent non-skin type cancer and the fifth most prevalent cancer type. Every year, more than 1.5 million women were diagnosed with breast cancer. It typically develops from the breast's inner lining, more especially from its lobules, and over...
A high-performance thin layer chromatography (HPTLC) method for the simultaneous quantitative determination of Lupeol and β- sitosterol in methanolic fraction of Achyranthes aspera leaves was developed. The separation of phytoconstituent was achieved using a mobile phase of toluene: ethyl acetate: formic acid (8:2:0.1, v/v/v). The densitometric determination was carried out at 550 and 525 nm...